From bd86efd972b46f19032d051e3381029eb33b27b8 Mon Sep 17 00:00:00 2001 From: Erik Grobecker Date: Thu, 5 Dec 2024 10:59:19 +0100 Subject: [PATCH] Biologie am 05.12.2024 --- INDEX.md | 1 + schule/bio/bio_2024-12-05.typ | 117 +++++++++++++++++++++++++++++ schule/bio/pdfs/bio_2024-12-05.pdf | Bin 0 -> 44464 bytes 3 files changed, 118 insertions(+) create mode 100644 schule/bio/bio_2024-12-05.typ create mode 100644 schule/bio/pdfs/bio_2024-12-05.pdf diff --git a/INDEX.md b/INDEX.md index 8d81256..1f8258d 100644 --- a/INDEX.md +++ b/INDEX.md @@ -37,6 +37,7 @@ | **Genetik:** CRISPR/Cas | 14.11.2024 | [hier](./schule/bio/pdfs/bio_2024-11-14.pdf) | | **Genetik:** Letzte Stunde vor der Klausur → Gelektrophorese/PCR | 25.11.2024 | [hier](./schule/bio/pdfs/bio_2024-11-25.pdf) | | **Genetik:** Präimplantsionsdiagnostik | 29.11.2024 | [hier](./schule/bio/pdfs/bio_2024-11-29.pdf) | +| **Genetik:** Wege der Tumorbildung und Prävention | 05.12.2024 | [hier](./schule/bio/pdfs/bio_2024-12-05.pdf) | [↟ table of contents](#table-of-contents) diff --git a/schule/bio/bio_2024-12-05.typ b/schule/bio/bio_2024-12-05.typ new file mode 100644 index 0000000..6594db3 --- /dev/null +++ b/schule/bio/bio_2024-12-05.typ @@ -0,0 +1,117 @@ +#import "@preview/grape-suite:1.0.0": exercise +#import exercise: project + +#set text(lang: "de") + +#show: project.with( + title: [Tumorbildung], + seminar: [Biologie Q2], + show-outline: true, + author: "Erik Grobecker", + date: datetime(day: 5, month: 12, year: 2024), + show-solutions: false, +) + +#show "->": sym.arrow +#show "=>": sym.arrow.double + += Tumorbildung + +== Proto-Onkogene und Onkogene + +*Pseudocode:* + +gesundes Ras-Protein: + +#rect()[ + ```py + if something: + ras_charged = True + + if ras_charged: + activate_signalchain = True + + if activate_signalchain: + build_protein_for_creation_of_cells() + ``` +] + +krankes Ras-Protein: + +#rect()[ + ```py + ras_charged = true + + if ras_charged: + activate_signalchain = True + + ... + ``` +] + +=== Plenum + +im gesunden Zustand: ++ Wachstumsfaktor aktiviert über Rezeptor Ras\ ++ Ras gibt Signal (über Signalkette) für Produktion/Aktivierung von Transkriptionsfaktor ++ gibt Signal für Genexpression von Protein XY ++ Protein XY gibt an Kontrollpunkten Signal zur "Weiterarbeit" ++ *Zellteilung!!* + +#text( + red.darken(20%), +)[Als Onkogen #footnote[also krank] ist Ras durch Mutation unabhängig vom Wachstumsfaktor dauerhaft aktiv -> Zellteilung!!] + +#pagebreak() + +== Tumor-Suppressorgene + +*Pseudocode:* + +gesundes p53-Protein + +#rect()[ + ```py + if signal_incoming: + transcribe() + + def transcribe(): + build("gene-p21") + ``` +] + +p21 wird verwendet um im Zellzyklus von der $G_1$-Phase zur $S$-Phase zu wechseln + +krankes p53-Protein + +#rect()[ + ```py + if signal_incoming: + do_nothing() + + ... + ``` +] +heißt das p53-Protein ist permanent inaktiv und die _Phase kann nicht gewechselt werden_ + +=== Plenum + +im gesunden Zustand: ++ wachstumhemmender Faktor bindet an Rezeptor ++ Rezeptor löst Moleküle einer hemmenden Signalkette aus ++ Signalkette ermöglicht RNA-Polymerase das Ablesen des P21 Gens ++ Genexpression für P21 (Protein für Hemmung der Zellteilung) findet statt ++ P21 gibt am Kontrollpunkt Signal zum "Stoppen" der Zellteilung ++ *keine Zellteilung!!* + +im kranken Zustand:\ +#text( + red.darken(20%), +)[Durch Mutation wirk P53 nicht mehr als Transkriptionsfaktor für P21, wodurch P21 nicht mehr expressiert werden kann und das Stop-Signal für Zellteilung fehlt -> Zellteilung!!] + +#pagebreak() + += Gebärmutterhalskrebs + +*Hausaufgabe:*\ +Therapiemöglichkeiten zusammenfassen diff --git a/schule/bio/pdfs/bio_2024-12-05.pdf b/schule/bio/pdfs/bio_2024-12-05.pdf new file mode 100644 index 0000000000000000000000000000000000000000..6cb9b9efee5d353a946792a499e70f43d6d61f56 GIT binary patch literal 44464 zcmce;1y~=+vOb)k0fM``1$TFMcL;95o#0MFaCd@Ba3{C~cXzko5F7&E{IX~7?%uQK z%K3lKrHf~np6c%Ep6;%xx2hpm6cwjqqUV4m_XB=lVL6BxiR_Ht!SeFL5)m<|zPC3e 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